SUANFARMA, in its desire to contribute to improving the health and quality of life of patients worldwide, provides pharmaceutical companies with one of the most important and powerful molecules to combat infections caused by bacteria in humans and animals, either by killing bacteria or by hindering their growth and multiplication: tetracyclines.
Own products
your partner to success
These antibiotics stop bacteria from reproducing and growing in living organisms, saving lives when used correctly.
In its commitment to the research and production of antibiotics, Cipan presents in its own product portfolio 3 generations of APIs derived from Tetracycline: Tetracycline, Minocycline, Lymecycline and Oxytetracycline. All of them are broad-spectrum natural bactericides extracted by fermentation from bacteria of the genus Streptomyces.
While Tetracycline, Minocycline and Lymecycline have a role as antibacterial agents more focused on human patients, Oxytetracycline provides the same virtues in animal health, especially in beekeeping and cattle, pigs, sheep, and goats.
Tetracycline HCI
Definition
Tetracycline belongs to a class of drugs called tetracycline antibiotics. Its main function is preventing the multiplication and spread of bacteria. Tetracyclines are bacteriostatic antibiotics that bind to the 30S subunit of the ribosome, thereby inhibiting bacterial protein synthesis.
Penetration of tetracyclines into most body fluids and tissues is excellent. Tetracyclines are distributed to varying degrees in bile, liver, lung, kidney, prostate, urine, cerebrospinal fluid, synovial fluid, sinus mucosa, brain, sputum, and bone. Tetracyclines cross the placenta and enter the fetal circulation and amniotic fluid.
After a single oral dose, peak plasma concentrations are reached in two to four hours.
Uses
One of its main uses is for treating the infections caused by bacteria, including pneumonia and other respiratory tract infections. It also helps with infections of the skin, eyes, lymphatic system, digestive system, reproductive system, and urinary system; as well as some infections that spread through ticks, lice, mites, and infected animals. It is also used with other medications to treat acne.
Tetracycline helps pests and tularemia (serious infections that can be spread on purpose as part of a bioterrorism attack). Furthermore, it can be used in patients who cannot be treated with penicillin, to treat certain types of food poisoning, and anthrax (a serious infection that can be deliberately spread as part of a bioterrorism attack).
Advantages
- Bacteriostatic action over a wide range of bacteria.
- Good safety profile and generally tolerable.
- Best cost-effectiveness in several European countries.
- It is rapidly and completely absorbed in the gastrointestinal tract, mainly in the small intestine, and reaches its maximum concentration in the blood within three to six hours.
- Parenterally it is optimally absorbed.
OXYTETRACYCLINE HCI
Definition
Oxytetracycline is a broad-spectrum antibiotic of the tetracycline group, used in pneumonias, enteritis, kerato conjunctivitis, arthritis, metritis, omphalitis, leptospirosis, actinobacillosis, anaplasmosis, mastitis or pietin.
It is a powder of crystalline nature, soluble in water and organic solvents.
Uses
This antibiotic is used in pneumonia, enteritis, kerato conjunctivitis, arthritis, metritis, omphalitis, leptospirosis, actinobacillosis , anaplasmosis, mastitis, pietin , infections in general, control of infectious diseases that affect bovines, sheep, goats and pigs, caused by sensitive germs to Oxytetracycline. It has activity against Gram positive and Gram-negative bacteria, including some mycoplasma and rickettsial species.
It also has activity against Gram-positive and Gram-negative bacteria, including some species of mycoplasmas and rickettsia.
Advantages
- Tetracycline derivative with similar action and indications.
- Bacteriostatic action over a wide range of bacteria.
- Good safety profile and is generally well tolerated.
- It presents well and offers complete absorption.
- The recommended dose ranges from 10 mg (if in combination with another antibiotic, such as Polymyxin B) to 30 mg (if the treatment is the only one).
Lymecycline
Definition
Tetracycline belongs to a class of drugs called tetracycline antibiotics. It works by preventing the multiplication and spread of bacteria.
Derived from Tetracycline, Lymecycline is a broad-spectrum tetracycline antibiotic. It is approximately 5,000 times more soluble than tetracycline base and is unique among tetracyclines in that it is absorbed by the active transport process through the intestinal tissue making use of the same fast and efficient mechanism by which carbohydrates are absorbed. The high level of absorption of Lymecycline allows it to be used at lower doses than the other tetracyclines; The standard dose of 408 mg is equivalent to 300 mg of tetracycline base. and in its action level at 600 mg of tetracycline hydrochloride.
Lymecycline, like other antibiotics, has been shown to be effective on a wide range of bacteria, and its good absorption profile makes it preferable to the use of tetracycline for the treatment of moderate to severe acne, and is usually prescribed for 8 weeks, but If no noticeable changes are seen within three weeks, other alternatives should be considered.
Uses
It is used in the treatment of moderate or severe acne, bronchitis, brucellosis, dental, conjunctivitis, enterocolitis, pharyngitis, inguinal granuloma, abdominal, biliary, skin and soft tissue, genitourinary and urinary infections, Lymphogranuloma venereum (sexually transmitted disease), acute otitis media, pneumonia, psittacosis, sinusitis, syphilis, trachoma, tularemia, urethritis and rectal infections.
Advantages
- Bacteriostatic action over a wide range of bacteria.
- Good safety profile and is generally well tolerated.
- Best cost-effectiveness in several European countries.
- It is rapidly and completely absorbed in the gastrointestinal tract, mainly in the small intestine, and reaches its maximum concentration in the blood within three to six hours.
- Parenterally it is optimally absorbed.
Minocycline HCI
Definition
Minocycline hydrochlorate, also simply known as minocycline, is an antibiotic of the tetracycline group. It is bacteriostatic, classified as a long-acting type (it achieves plasma activities 2-4 times higher than its congeners.). Minocycline is frequently used for the treatment of acne vulgaris and rosacea.
It is an antibiotic from the tetracycline group. As a result of its longer half-life, it achieves plasma activities 2-4 times greater than its congeners (150 mg of minocycline demonstrated about 6 times greater activity than 250 mg of tetracycline within 24-48 h).
Uses
It is mainly used in the treatment of acne and rosacea, since the single dose of 100 mg/day leads to a much greater therapeutic adherence than the four daily doses required with tetracycline and oxytetracycline.
While its antibiotic spectrum has been shown to be much higher than other members, including activity against Neisseria meningitidis, its prophylactic use has not been authorized due to its adverse effects (dizziness and vertigo).
It can be used to treat Acinetobacter infections, resistant to multiple drugs. The other uses of Minocycline are shared with the other members of the Tetracyclines group.
Advantages
- A single dose of 100 mg/day leads to a much higher therapeutic adherence than the four daily doses required with tetracycline and oxytetracycline.
- A very wide antibiotic spectrum of action, even wider than Doxycycline.
- Minocycline presents activity against Neisseria meningitidis.
- It can be used to treat multidrug-resistant Acinetobacter infections.
- Minocycline shows a better pharmacokinetic profile than the first-generation tetracyclines.
- As a result of its longer half-life, it achieves plasma activities 2-4 times greater than Tetracycline.
- FDA and European approval for the treatment of infections caused by a wide range of gram-positive and gram-negative organisms, including Cholera, Gonorrhoea or Anthrax.
- One of the advantages of this drug is its low development of resistance in bacteria, which is why it has been used in polymicrobial diseases such as acne and has become very popular with dermatologists.
- Tetracycline HCI
Tetracycline HCI
Definition
Tetracycline belongs to a class of drugs called tetracycline antibiotics. Its main function is preventing the multiplication and spread of bacteria. Tetracyclines are bacteriostatic antibiotics that bind to the 30S subunit of the ribosome, thereby inhibiting bacterial protein synthesis.
Penetration of tetracyclines into most body fluids and tissues is excellent. Tetracyclines are distributed to varying degrees in bile, liver, lung, kidney, prostate, urine, cerebrospinal fluid, synovial fluid, sinus mucosa, brain, sputum, and bone. Tetracyclines cross the placenta and enter the fetal circulation and amniotic fluid.
After a single oral dose, peak plasma concentrations are reached in two to four hours.
Uses
One of its main uses is for treating the infections caused by bacteria, including pneumonia and other respiratory tract infections. It also helps with infections of the skin, eyes, lymphatic system, digestive system, reproductive system, and urinary system; as well as some infections that spread through ticks, lice, mites, and infected animals. It is also used with other medications to treat acne.
Tetracycline helps pests and tularemia (serious infections that can be spread on purpose as part of a bioterrorism attack). Furthermore, it can be used in patients who cannot be treated with penicillin, to treat certain types of food poisoning, and anthrax (a serious infection that can be deliberately spread as part of a bioterrorism attack).
Advantages
- Bacteriostatic action over a wide range of bacteria.
- Good safety profile and generally tolerable.
- Best cost-effectiveness in several European countries.
- It is rapidly and completely absorbed in the gastrointestinal tract, mainly in the small intestine, and reaches its maximum concentration in the blood within three to six hours.
- Parenterally it is optimally absorbed.
- Oxytetracycline HCI
OXYTETRACYCLINE HCI
Definition
Oxytetracycline is a broad-spectrum antibiotic of the tetracycline group, used in pneumonias, enteritis, kerato conjunctivitis, arthritis, metritis, omphalitis, leptospirosis, actinobacillosis, anaplasmosis, mastitis or pietin.
It is a powder of crystalline nature, soluble in water and organic solvents.
Uses
This antibiotic is used in pneumonia, enteritis, kerato conjunctivitis, arthritis, metritis, omphalitis, leptospirosis, actinobacillosis , anaplasmosis, mastitis, pietin , infections in general, control of infectious diseases that affect bovines, sheep, goats and pigs, caused by sensitive germs to Oxytetracycline. It has activity against Gram positive and Gram-negative bacteria, including some mycoplasma and rickettsial species.
It also has activity against Gram-positive and Gram-negative bacteria, including some species of mycoplasmas and rickettsia.
Advantages
- Tetracycline derivative with similar action and indications.
- Bacteriostatic action over a wide range of bacteria.
- Good safety profile and is generally well tolerated.
- It presents well and offers complete absorption.
- The recommended dose ranges from 10 mg (if in combination with another antibiotic, such as Polymyxin B) to 30 mg (if the treatment is the only one).
- Lymecycline
Lymecycline
Definition
Tetracycline belongs to a class of drugs called tetracycline antibiotics. It works by preventing the multiplication and spread of bacteria.
Derived from Tetracycline, Lymecycline is a broad-spectrum tetracycline antibiotic. It is approximately 5,000 times more soluble than tetracycline base and is unique among tetracyclines in that it is absorbed by the active transport process through the intestinal tissue making use of the same fast and efficient mechanism by which carbohydrates are absorbed. The high level of absorption of Lymecycline allows it to be used at lower doses than the other tetracyclines; The standard dose of 408 mg is equivalent to 300 mg of tetracycline base. and in its action level at 600 mg of tetracycline hydrochloride.
Lymecycline, like other antibiotics, has been shown to be effective on a wide range of bacteria, and its good absorption profile makes it preferable to the use of tetracycline for the treatment of moderate to severe acne, and is usually prescribed for 8 weeks, but If no noticeable changes are seen within three weeks, other alternatives should be considered.
Uses
It is used in the treatment of moderate or severe acne, bronchitis, brucellosis, dental, conjunctivitis, enterocolitis, pharyngitis, inguinal granuloma, abdominal, biliary, skin and soft tissue, genitourinary and urinary infections, Lymphogranuloma venereum (sexually transmitted disease), acute otitis media, pneumonia, psittacosis, sinusitis, syphilis, trachoma, tularemia, urethritis and rectal infections.
Advantages
- Bacteriostatic action over a wide range of bacteria.
- Good safety profile and is generally well tolerated.
- Best cost-effectiveness in several European countries.
- It is rapidly and completely absorbed in the gastrointestinal tract, mainly in the small intestine, and reaches its maximum concentration in the blood within three to six hours.
- Parenterally it is optimally absorbed.
- Minocycline HCI
Minocycline HCI
Definition
Minocycline hydrochlorate, also simply known as minocycline, is an antibiotic of the tetracycline group. It is bacteriostatic, classified as a long-acting type (it achieves plasma activities 2-4 times higher than its congeners.). Minocycline is frequently used for the treatment of acne vulgaris and rosacea.
It is an antibiotic from the tetracycline group. As a result of its longer half-life, it achieves plasma activities 2-4 times greater than its congeners (150 mg of minocycline demonstrated about 6 times greater activity than 250 mg of tetracycline within 24-48 h).
Uses
It is mainly used in the treatment of acne and rosacea, since the single dose of 100 mg/day leads to a much greater therapeutic adherence than the four daily doses required with tetracycline and oxytetracycline.
While its antibiotic spectrum has been shown to be much higher than other members, including activity against Neisseria meningitidis, its prophylactic use has not been authorized due to its adverse effects (dizziness and vertigo).
It can be used to treat Acinetobacter infections, resistant to multiple drugs. The other uses of Minocycline are shared with the other members of the Tetracyclines group.
Advantages
- A single dose of 100 mg/day leads to a much higher therapeutic adherence than the four daily doses required with tetracycline and oxytetracycline.
- A very wide antibiotic spectrum of action, even wider than Doxycycline.
- Minocycline presents activity against Neisseria meningitidis.
- It can be used to treat multidrug-resistant Acinetobacter infections.
- Minocycline shows a better pharmacokinetic profile than the first-generation tetracyclines.
- As a result of its longer half-life, it achieves plasma activities 2-4 times greater than Tetracycline.
- FDA and European approval for the treatment of infections caused by a wide range of gram-positive and gram-negative organisms, including Cholera, Gonorrhoea or Anthrax.
- One of the advantages of this drug is its low development of resistance in bacteria, which is why it has been used in polymicrobial diseases such as acne and has become very popular with dermatologists.